Dorsey Lab

Meet the PI

Jay Dorsey, MD, PhD is an NIH-funded physician-scientist, Co-Leader of the Radiation Oncology Translational Center of Excellence, and a board-certified therapeutic radiologist. As a tenured Associate Professor at the University of Pennsylvania, he brings extensive expertise in cancer and radiation biology, genomics, biomarkers, and cancer nanotechnology, advancing innovative approaches in cancer research and patient care.

Meet the PIMeet the PI

Our Mission

The Dorsey Lab is dedicated to deciphering the intricate and complex interactions between cancer, the tumor microenvironment, and treatment response. Our mission is to uncover novel immune, molecular, and therapeutic insights, with a strong emphasis on reverse translation—bringing clinical discoveries back to the lab to inspire breakthroughs that drive the future of cancer treatment.

Featured Publications

Novel Combination Treatment for Melanoma: FLASH Radiotherapy and Immunotherapy Delivered by a Radiopaque and Radiation Responsive Hydrogel

Dong YC, Nieves LM, Hsu JC, Kumar A, Bouché M, Krishnan U, Mossburg KJ, Saxena D, Uman S, Kambayashi T, Burdick JA, Kim MM, Dorsey JF, Cormode DP. Novel Combination Treatment for Melanoma: FLASH Radiotherapy and Immunotherapy Delivered by a Radiopaque and Radiation Responsive Hydrogel. Chem Mater. 2023 Nov 28;35(22):9542-9551. doi: 10.1021/acs.chemmater.3c01390. Epub 2023 Nov 14. PMID: 38933522; PMCID: PMC11198981.

A Prospective Phase I/II Clinical Trial of High- Dose Proton Therapy for Chordomas and Chondrosarcomas

Dastgheyb SS, Dreyfuss AD, LaRiviere MJ, Mohiuddin JJ, Baumann BC, Shabason J, Lustig RA, Dorsey JF, Lin A, Grady SM, O’Malley BW, Lee JYK, Newman JG, Schuster JM, Alonso-Basanta M. A Prospective Phase I/II Clinical Trial of High- Dose Proton Therapy for Chordomas and Chondrosarcomas. Adv Radiat Oncol. 2024 Feb 8;9(5):101456. doi: 10.1016/j.adro.2024.101456. PMID: 38550376; PMCID: PMC10972808.

An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma

Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv. 2024 Mar;10(9):eadj4678. doi:10.1126/sciadv.adj4678. Epub 2024 Feb 28. PMID: 38416830; PMCID: PMC10901371.

Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy

Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y. Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nat Protoc. 2024 Apr;19(4):1053-1082. doi:10.1038/s41596-023-00941-5. Epub 2024 Jan 11. PMID: 38212641.

Learn MoreLearn More
mobile-nav